The exact cause isn’t fully understood, but it’s believed to involve:

  • Genetic Factors:
    • HLA-B27 is a key genetic marker associated with AS.
  • Autoimmune Response:
    • The immune system mistakenly attacks healthy joints and tissues.

 

How Is Ankylosing Spondylitis Diagnosed?

  1. Medical History and Physical Exam:
    • Doctors look for patterns of pain, stiffness, and family history of AS.
  2. Imaging Tests:
    • X-rays or MRI can show inflammation or structural changes in the spine and sacroiliac joints.
  3. Blood Tests:
    • Testing for HLA-B27 or markers of inflammation, like C-reactive protein (CRP).

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